Protein-Benign Microencapsulation with a Water/Oil Microemulsion formed by a Biodegradable Polymer Surfactant
), H. Yoshizawa(2), K. Shiomori(3),
(1) Department of Chemical Engineering, Nara National College of Technology
(2) Department of Chemical Engineering, Nara National College of Technology
(3) Department of Applied Chemistry, University of Miyazaki
Corresponding Author
Abstract
The amphiphilic biodegradable polymer surfactant, poly(ethylene oxide monooleate)-block- poly(D,L-lactide) (MOPEO-PLA), was shown to form microemulsions in organic solvent and to dissolve cytochrome c into their microemulsions at high concentration with native form. The microemulsions dissolving cytochrome c provided a new preparation route of polylactide microcapsules enclosing cytochrome c, which exhibited high entrapment of proteins in the microcapsules and sustained long-term release. A MOPEO-PLA microemulsion system would provide a new encapsulation system with a biodegradable polymer matrix for delivery of proteins and peptides.
Keywords
biodegradable microcapsules; polymer microemulsion; PLA; long-term release
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