Protein-Benign Microencapsulation with a Water/Oil Microemulsion formed by a Biodegradable Polymer Surfactant
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(1) Department of Chemical Engineering, Nara National College of Technology
(2) Department of Chemical Engineering, Nara National College of Technology
(3) Department of Applied Chemistry, University of Miyazaki
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Abstract
The amphiphilic biodegradable polymer surfactant, poly(ethylene oxide monooleate)-block- poly(D,L-lactide) (MOPEO-PLA), was shown to form microemulsions in organic solvent and to dissolve cytochrome c into their microemulsions at high concentration with native form. The microemulsions dissolving cytochrome c provided a new preparation route of polylactide microcapsules enclosing cytochrome c, which exhibited high entrapment of proteins in the microcapsules and sustained long-term release. A MOPEO-PLA microemulsion system would provide a new encapsulation system with a biodegradable polymer matrix for delivery of proteins and peptides.
Keywords
biodegradable microcapsules; polymer microemulsion; PLA; long-term release
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