[ Abstract ]

Matrix Metalloproteinase-9 (MMP-9) is the major MMP involved in normal delivery and also plays an important role in pathological processes leading to preterm delivery. This research aimed to compare the levels of Matrix Metalloproteinase-9 (MMP-9) in pre-term and A-term deliveries. The research method used was observationallanalytical method with the cross sectional approach. The samples comprised 18 mothers with pre-term delivery and 20 mothers with a-term delivery. The levels of MMP-9 were examined using ELISA method, and the data were analyzed using Shapiro-Wilk normality test, Mann-Whitney test, and Chi square test. The research results indicated that he mean level of MMP-9 serum in preterm group was 2242.84 ± 1131.76 ng/L, while the mean level of MMP-9 serum in a-term group was 1315.94 ± 376.96 ng/L. Tus, the result of the analysis test, the level of MMP-9 serum in pre-term delivery was higher compared to that in a-term delivery. This difference, statistically, was significant since the value of p 0.002 (p<0.05).

 

Keywords: MMP-9, delivery, pre-term, aterm


[ Abstrak ]

Matrix Metalloproteinase-9 (MMP-9) adalah MMP utama yang terlibat dalam persalinan normal dan juga memainkan peran penting dalam proses-proses patologis yang menyebabkan persalinan preterm.Penelitian ini bertujuan membandingkan kadar MMP-9 serum pada persalinan preterm dan aterm. Metode yang digunakan adalah observasi analitik dengan pendekatan cross sectional Sampel adalah ibu dengan persalinan preterm sebanyak 18 orang dan aterm sebanyak 20 orang. Kadar MMP-9 diperiksa dengan metode ELISA. Data dianalisis menggunakan uji normalitas Shapiro-Wilk, uji Mann-Withney, dan uji chi- Square. Hasil penelitian menunjukkan bahwa rerata kadar MMP-9 serum kelompok preterm, yaitu 2242,84 ± 1131,76 ng/L, sedangkan rerata kadar MMP-9 serum kelompok aterm, yaitu 1315,94 ± 376, 96 ng/L. Berdasarkan uji analisis kadar serum MMP-9 pada persalinan, preterm lebih tinggi dibandingkan dengan persalinan aterm. Perbedaan ini secara statistik bermakna dilihat danri hasil p 0,002 (p 0,05).

 

Kata kunci: MMP-9, persalinan, preterm, aterm